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目的探讨糖尿病慢性肾脏疾病(CKD)患者血清瘦素(Lep)和血脂水平的变化及其临床意义。方法根据UAER水平将120例T2DM患者分为<30mg/24h组41例、30~299mg/24h组44例和≥300mg/24h组35例,另选取健康志愿者40名作为对照(NC)组。检测FPG、HbA1c、Lep及血脂各项。结果 CKD各组FPG、HbA1c、Lep、TG、TC、LDL-C水平均高于NC组,HDL-C低于NC组(P<0.05)。30~299mg/24h组和≥300mg/24h组FPG、HbA1c、Lep、TC、TG、LDL-C水平高于<30mg/24h组,HDL-C低于<30mg/24h组,且≥300mg/24h组高于30~299mg/24h组(P<0.05)。Lep水平与UAER呈正相关(P<0.01)。结论 CKD患者HbA1c、Lep、血脂水平均升高,且与微血管病变程度有关,提示HbA1c、Lep、血脂水平可预测CKD的进展。
Objective To investigate the changes of serum leptin (Lep) and serum lipids in patients with chronic kidney disease (CKD) and its clinical significance. Methods According to the level of UAER, 120 patients with T2DM were divided into three groups: 41 cases in 30mg / 24h group, 44 cases in 30-299mg / 24h group and 35 cases in 300mg / 24h group. Forty healthy volunteers were selected as control group. Detection of FPG, HbA1c, Lep and blood lipids. Results The levels of FPG, HbA1c, Lep, TG, TC and LDL-C in CKD group were higher than those in NC group and HDL-C was lower than that in NC group (P <0.05). The levels of FPG, HbA1c, Lep, TC, TG and LDL-C in 30 ~ 299mg / 24h group and≥300mg / 24h group were higher than <30mg / 24h group, HDL-C <30mg / 24h group and≥300mg / 24h Group higher than 30 ~ 299mg / 24h group (P <0.05). Lep level was positively correlated with UAER (P <0.01). Conclusions The levels of HbA1c, Lep, and lipids in patients with CKD are all elevated, which are correlated with the degree of microvascular disease. It suggests that the levels of HbA1c, Lep and blood lipid can predict the progression of CKD.