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目的：研究重型脑外伤患者血清IL-8和TNF-α表达与术后颅内压（ICP）之间的关系。方法重型脑外伤手术患者29例。术中放置颅内测压导管监测IC P；术后每12小时记录IC P ，采用ELISA法检测血清IL-8和TNF-α水平，分析血清IL-8和TNF-α水平与患者预后的关系。结果患者术后血清IL-8及TNF-α水平与ICP均呈正相关（P＜0．01）。患者获6～17（8.2±5.3）个月随访。术后6个月格拉斯哥预后扩展量表（GOSE）评分（4.0±2.4）分，死亡7例（24.1％）。29例中，预后良好13例（44.8％），血清IL-8为20.3（12.6，30.7）pg／ml；TNF-α为4.7（2.5，8.6）pg／ml；预后不良16例（55.2％），血清IL-8为77.2（29.5，144．6）pg／ml ，TNF-α为10.1（5.7，19.2）pg／ml；预后良好患者血清IL-8和TNF-α水平低于预后不良患者（P＜0．01）。结论血清IL-8和 TNF-α水平可反映脑外伤患者术后IC P变化，对判断患者病情和预后有重要意义。“,”Objective To investigate the relationship of serum IL-8 and TNF-αexpressions and intracranial pressure(ICP) in the patients with severe traumatic brain injury (TBI) .Methods ICP after surgery was monitored in 29 patients with severe TBI .Serum expressions of IL-8 and TNF-αwere detected by ELISA every 12 hours after surgery .The relationship of serum IL-8 and TNF-αexpressions and ICP was analyzed .Results Serum expressions of IL-8 and TNF-αafter surgery were positively correlated with ICP (P<0 .01) .The patients were followed up for 6-17(8.2 ± 5.3) months , which showed that 7 cases died and Glasgow prognostic extension scale(GOSE) score of survival cases was (4.0 ± 2.4)points in the 6th month after operation .Serum expressions of IL-8 and TNF-α after surgery were lower in 13 cases with good prognosis(GOSE 5-8 points) than those in 16 cases with poor prognosis(GOSE 1-4 points) [(20.3 pg/ml vs .77.2 pg/ml) and (4.7 pg/ml vs .10.1 pg/ml)] (P<0 .01) .Conclusion Serum expressions of IL-8 and TNF-αafter surgery may reflect the changes of ICP and are helpful in evaluating illness state and prognosis of patients with severe TBI .