目的探讨经单鼻孔蝶窦入路显微切除垂体腺瘤手术技巧以及并发症的处理方法。方法回顾性分析我科经单鼻孔蝶窦入路显微切除垂体腺瘤22例,采用经鼻蝶入路切除肿瘤,术中将扩鼻器直抵蝶窦前壁,将鼻中隔完整地推向对侧,凿除蝶窦前壁骨质,经鞍底切除肿瘤。结果全切除16例,大部切除6例,无严重并发症发生,无死亡。结论经单鼻孔蝶窦入路显微切除垂体腺瘤创伤小,安全性高,术后患者恢复快,对于位于鞍内和大部位于鞍内的垂体瘤是一种有效的术式。 Objective To investigate the surgical techniques and complications of microsurgical removal of pituitary adenomas by single nostril sphenoid approach. Methods Retrospective analysis of 22 cases of microsurgical excision of pituitary adenomas by single nostril sphenoid sinus approach in our department. The tumors were removed by transnasal approach. The nasal openers were directly advanced to the anterior wall of the sphenoid sinus during operation. The nasal septum was completely pushed to the right Side, chisel ex anterior wall of the sphenoid bone, the sellar resection of the tumor. Results Total resection in 16 cases, most resection in 6 cases, no serious complications, no death. Conclusions The microsurgical removal of pituitary adenomas by single nostril sphenoid sinus approach is characterized by less trauma, higher safety and quick recovery after operation. It is an effective surgical procedure for pituitary adenomas located in the saddle and most of the pituitary adenomas.