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目的:制备沙美特罗白蛋白微球,并考察其体外释放性能。方法:以白蛋白为载体,采用乳化交联法制备沙美特罗白蛋白微球。在单因素考察的基础上,利用正交设计优化沙美特罗白蛋白微球制备工艺,并对微球的粒径,形态,体外释放特性进行研究。结果:制得的微球形态圆整,平均粒径为(16.82±1.25)μm,平均载药量为(52.08±3.26)%,平均包封率为(60.54±3.17)%,体外释放符合Higuchi方程,Q=11.5846t_(1/2)-1.207(r=0.9985)。结论:沙美特罗白蛋白微球体外释放特性符合长效制剂特征。
OBJECTIVE: To prepare salmeterol albumin microspheres and study its in vitro release properties. Methods: Salmeterol microspheres were prepared by emulsion cross - linking using albumin as carrier. On the basis of single factor investigation, the orthogonal design was used to optimize the preparation process of salmeterol microsphere, and the particle size, morphology and in vitro release characteristics of microsphere were studied. Results: The morphology of the prepared microspheres was round and the mean diameter was (16.82 ± 1.25) μm. The average drug loading was (52.08 ± 3.26)% and the average encapsulation efficiency was (60.54 ± 3.17)%. Equation, Q = 11.5846t_ (1/2) -1.207 (r = 0.9985). Conclusion: The in vitro release characteristics of salmeterol albumin microspheres conform to the characteristics of long-acting preparations.