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目的 探讨血中透明质酸 (HA)变化对狼疮肾炎活动度的评价。方法 对 30例狼疮肾炎患者作肾活检并按病理组织学分析计算狼疮活动积分 ,用放射免疫分析法测定血中HA浓度 ,分析狼疮肾炎组HA浓度变化与肾脏狼疮活动积分高低的相关性 ,并对比研究 5 4例慢性肾小球肾炎病人的血清HA变化。结果 狼疮肾炎患者血中HA浓度与狼疮活动度呈明显正相关 (P <0 0 0 1) ,狼疮活动控制后血中HA明显下降 (P <0 0 1) ,狼疮性肾炎组HA浓度明显高于慢性肾炎组。结论 测定血中HA浓度可作为评估狼疮活动的指标之一。
Objective To investigate the changes of blood hyaluronic acid (HA) in evaluating the activity of lupus nephritis. Methods Thirty patients with lupus nephritis were screened for renal biopsy. The lupus activity scores were calculated by histopathological analysis. The concentration of HA in serum was determined by radioimmunoassay. The correlation between HA concentration in lupus nephritis group and activity score of renal lupus was analyzed. Comparative study of 54 cases of chronic glomerulonephritis in patients with serum HA changes. Results The concentration of HA in lupus nephritis patients was positively correlated with the activity of lupus (P <0.01). The level of HA in blood decreased significantly after lupus activity control (P <0.01), and the concentration of HA in lupus nephritis group was significantly higher In chronic nephritis group. Conclusion Determination of blood HA concentration can be used as an indicator of lupus activity.