Purpose: To determine the efficacy of echography with new generation contrast agents in visualizing vascularization of choroidal malignant melanomas. Methods: An echographic contrast medium consisting of phospholipidic microbubbles filled with sulphur hexafluoride (Sonovue(r)) was used to visualize microcirculation i n 25 cases of choroidal lesions already diagnosed with standardized echography ( 21 choro- idal malignant melanomas, four disciform lesions). Results: In untreated malig nant melanomas contrast agent echography revealed the presence of a dense microc irculation inside the mass. In one case vitreal seeding of the contrast agent wa s detectable before enucleation and histological examination revealed the presen ce of tumoral cells. In 12 cases treated with transpupillary thermotherapy, cont rast agent echographic evaluation showed heavy regression of microcirculation af ter l week, confirmed in one case by histology, and a reduction of 70-80%in di mensions after 6 months (which appeared to have stabilized at subsequent examina tions). In four cases treated with proton beam brachytherapy 2 years prior to ou r examination, contrast agent echography showed the absence of a microvascular n etwork and the presence of large vessels and blood lakes. In four cases of disci form lesion, deep and superficial retina-associated vascularization was observe d, with a weak spread of contrast agent inside the lesion. Conclusion: Live repr esentation with good resolution of choroidal malignant melanoma microcirculation was obtained. Methods: An echographic contrast medium consisting of phospholipidic microbubbles filled with sulfur hexafluoride (Sonovue (r)) was used to visualize microcirculation in 25 cases of Choroidal lesions have been diagnosed with standardized echography (21 choro- idal malignant melanomas, four disciform lesions). Results: In untreated malig nant melanomas contrast agent echography revealed the presence of a dense microcirculation inside the mass. In one case vitreal seeding of the contrast agent wa s detectable before enucleation and histological examination revealed the presen ce of tumoral cells. In 12 cases treated with transpupillary thermotherapy, cont rast agent echographic evaluation showed heavy regression of microcirculation last week, confirmed in one case by histology, and a reduction of 70-80% in di mensions after 6 months (wh In four cases treated with proton beam brachytherapy 2 years prior to ou r examination, contrast agent echography showed the absence of a microvascular n etwork and the presence of large vessels and blood lakes. In four cases of disci form lesion, deep and superficial retina-associated vascularization was observe d, with a weak spread of contrast agent inside the lesion. Conclusion: Live repr esentation with good resolution of choroidal malignant melanoma microcirculation was obtained.