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目的制备复方穿蛭透皮贴并考察其体外透皮吸收和释放度行为,为其制剂开发提供依据。方法以聚丙烯酸酯、氮酮、丙二醇、薄荷醇为材料制备复方穿蛭透皮贴,按《中国药典》方法测定体外释放度,采用改良Franz扩散池考察透皮贴的体外释放性能。结果复方穿蛭透皮贴的体外释药符合零级动力学方程。结论复方穿蛭透皮贴制备工艺简单,具有良好的体外经皮渗透作用。
Objective To prepare compound transdermal transdermal patch and investigate its transdermal absorption and release behavior in vitro, and provide basis for the development of its preparation. Methods The compound transdermal transdermal patch was prepared with polyacrylate, azone, propylene glycol and menthol as materials. The in vitro release rate was determined according to the method of “Chinese Pharmacopoeia”. The in vitro release performance of the transdermal patch was investigated using a modified Franz diffusion cell. Results The in vitro release of compound transdermal transdermal patch complied with the zero-order kinetic equation. Conclusion The preparation of compound transdermal transdermal patch is simple and has good transdermal permeation in vitro.