有关稀土的毒性研究,本世纪初国外即有报告。但国内稀土粉尘肺内沉着及其毒理学方面的报道较少。为此,我们对二氧化铈作了气管内注入染尘的肺内沉着症及其毒性实验,为制订车间空气中二氧化铈粉尘卫生标准提供科学依据。一、二氧化铈急性毒性实验1.材料和方法:①二氧化铈粉末为分析纯,含量99.9%,用离子交换水配成40%的混悬液,煮沸消毒备用;②选用体重19.5～21g健康小白鼠40只,雌雄各半,分为4组,每组10只,分别按10000 ml/kg体重给予一次灌胃及腹腔注射,对照组给予注射用水,每 The toxicology of rare earth, foreign countries that have been reported early this century. However, there are few reports about the deposition of rare earth dust in the lungs and their toxicology. To this end, we made ciclosporin intratracheal injection of dust-induced intrapulmonary disease and its toxicity experiments, in order to develop workshop air ceria dust health standards provide a scientific basis. First, the acute toxicity test of ceria 1. Materials and methods: ① ceria powder for the analysis of pure, content 99.9%, with 40% of the ion exchange water dubbed boiled disinfection reserve; ② weight 19.5 ~ 21g Healthy mice 40, male and female, divided into 4 groups of 10, respectively, according to 10000 ml / kg body weight given intragastric and intraperitoneal injection, the control group given water for injection, each