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目的:探索治疗肝硬化并发的原发性腹膜炎的有效方法,选择疗效显著的抗菌药物。方法:应用氨曲南短程(5天)治疗肝硬化并原发性腹膜炎,观察患者血白细胞和腹水细胞计数、患者症状和体征(发热、腹痛、腹部压痛及反跳痛等)的变化。结果:肝硬化并发的原发性腹膜炎经氨曲南治疗48小时,血中白细胞数、中性粒细胞比例和腹水细胞数显著降低(P<0.01);治疗5天后,患者临床症状和体征明显改善。结论:氨曲南治疗肝硬化并发原发性腹膜炎疗效可靠,无明显不良反应,可作为经验用药的选择。
Objective: To explore an effective method of treating primary peritonitis complicated by cirrhosis, and to select antibacterial drugs with significant curative effect. Methods: Aztreonam short-course (5 days) was used to treat cirrhosis and primary peritonitis. The counts of leukocytes and ascites were observed. The symptoms and signs of the patients (fever, abdominal pain, abdominal tenderness and rebound pain) were observed. Results: Primary peritonitis with cirrhosis complicated with aztreonam for 48 hours showed a significant decrease in the number of leukocytes, neutrophils and ascites cells (P <0.01). After 5 days of treatment, the clinical symptoms and signs of the patients were obvious improve. Conclusion: Aztreonam treatment of cirrhosis complicated with primary peritonitis has reliable curative effect and no obvious adverse reactions, which can be used as the choice of experience medication.