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目的:研究急性白血病儿童用不同方案大剂量阿糖胞苷(3 g·m~(-2),VD,q12h)化疗后的药物动力学。方法:采用HPLC法测定患者首、末次给药后阿糖胞苷及代谢物阿糖尿苷血药浓度。结果:大剂量长程连续化疗时,阿糖胞苷及阿糖尿苷浓度下降均较明显,短程化疗时阿糖胞苷及阿糖尿苷血浓度则较稳定。结论:大剂量阿糖胞苷长程化疗易致耐药及引起严重不良反应,短程化疗较为安全、有效。
AIM: To study the pharmacokinetics of children with acute leukemia after chemotherapy with high-dose cytarabine (3 g · m -2, VD, q12h). Methods: HPLC method was used to determine the concentration of cytarabine and metabolite arabinoside in the patients before and after the last administration. Results: The concentration of cytarabine and arabinoside decreased significantly when treated with high dose of long-term continuous chemotherapy. The blood concentrations of cytarabine and arabinouridine were stable in short-term chemotherapy. CONCLUSION: High-dose cytarabine is susceptible to long-term chemotherapy and causes serious adverse reactions. Short-course chemotherapy is safe and effective.