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目的采用meta分析的方法评价RUNX3基因启动子甲基化与胃癌发生的关系。方法检索公开发表在Pubmed、EMBASE、Ovid、中国期刊全文数据库(CNKI)关于RUNX3基因启动子甲基化与胃癌发生关系的研究。应用Stata11.0统计软件分析RUNX3基因启动子甲基化与胃癌发生间的关联。结果共有19项研究纳入分析,meta分析结果显示:胃癌患者癌组织中RUNX3基因启动子甲基化发生率为P=55%(95%CI:45%~66%);胃癌患者远癌正常胃组织中RUNX3基因启动子甲基化发生率为P=18%(95%CI:7%~29%)。与远癌正常胃组织相比,胃癌组织中RUNX3基因启动子甲基化发生优势比OR=7.85(95%CI:5.81~10.61)。结论胃癌患者癌组织中RUNX3基因启动子甲基化发生率明显高于远癌正常胃组织,RUNX3基因启动子甲基化可能与胃癌的发生密切相关。
Objective To evaluate the relationship between RUNX3 promoter methylation and gastric carcinogenesis by meta-analysis. Methods PubMed, EMBASE, Ovid, CNKI were used to study the relationship between RUNX3 promoter methylation and gastric cancer. Stata11.0 statistical software was used to analyze the association between RUNX3 promoter methylation and gastric carcinogenesis. Results A total of 19 studies were included in the analysis. The meta-analysis showed that the promoter methylation of RUNX3 gene in gastric cancer was P = 55% (95% CI: 45% -66%); The incidence of RUNX3 promoter methylation in tissues was P = 18% (95% CI: 7% -29%). Compared with the normal gastric tissue far cancer, RUNX3 gene promoter methylation in gastric cancer odds ratio OR = 7.85 (95% CI: 5.81 ~ 10.61). Conclusion The incidence of promoter methylation of RUNX3 gene in gastric cancer is significantly higher than that in normal gastric cancer. The methylation of RUNX3 promoter may be closely related to the occurrence of gastric cancer.