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人体在防御和清除入侵病原体等异物时,有一种使白细胞趋集的功能,有一些低分子量的物质能引起这种功能称之为趋化剂或趋化因子。这些小蛋白因其有定向细胞趋化作用而得名。经研究表明,趋化因子受体3(CXCR3)趋化因子可能在自身免疫内分泌疾病中起到致病作用。此外,血清中CXCR3趋化因子的判定可能辅助检测免疫活性。CXCR3和优先参与趋化Th1细胞的因子。该受体连接的趋化因子10(CXCL10)不仅参与白细胞募集,还诱导T细胞增殖的异源体和抗原的刺激。趋化因子10正调节Th1细胞产物并且负调节Th2细胞的产物。免疫反应纤维结合素(INF)产物可增强特异的炎症反应。当被激活或者发现炎症和肿瘤细胞后趋化因子受体3-B在内皮细胞中表达并且其结合的趋化因子10,趋化因子9和趋化因子11激活后产生血管抑制作用。
The human body in the defense and clearance of invasion of foreign bodies such as pathogens, there is a leukocyte aggregation function, there are some low-molecular weight substances can cause this function called chemotaxis or chemokines. These small proteins are named for their directed chemotaxis. Studies have shown that chemokine receptor 3 (CXCR3) chemokines may play a causative role in autoimmune endocrine diseases. In addition, the determination of CXCR3 chemokines in serum may assist in the detection of immunocompetence. CXCR3 and factors that preferentially participate in chemotactic Th1 cells. The receptor-linked chemokine 10 (CXCL10) not only participates in leukocyte recruitment but also induces stimulation of T-cell proliferation of heterologous bodies and antigens. Chemokine 10 positively regulates Th1 cell production and negatively regulates the production of Th2 cells. Immune response fibronectin (INF) products enhance the specific inflammatory response. Chemokine receptor 3-B is expressed in endothelial cells upon activation or upon detection of inflammatory and tumor cells and produces vasoconstriction upon its binding of chemokine 10, chemokine 9 and chemokine 11.