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有研究表明,早期抗生素的使用增加了儿童肠炎、超重和哮喘的风险。成人试验研究表明,口服抗生素能明显改变肠道微生物菌群,减少菌群的多样性,改变菌群的构成,但其样本量非常有限。在新生儿中使用抗生素治疗者和未使用抗生素治疗者其体内肠道微生物菌群存在较大差异,但至今尚不清楚早期使用抗生素对儿童肠道微生物菌群的远期影响。为探讨早期抗生素使用对儿童肠道微生物群影响的远期效应,Korpela及其研究团队查阅了142名2~7岁儿童早期抗
Studies have shown that the use of early antibiotics increases the risk of colitis, overweight and asthma in children. Adult experimental studies have shown that oral antibiotics can significantly change the gut microbial flora, reduce bacterial diversity and change the composition of the flora, but its sample size is very limited. There is a large difference in intestinal microflora in vivo between newborns treated with antibiotics and those not treated with antibiotics, but the long-term effects of early antibiotics on intestinal microflora in children are not yet known. To explore the long-term effects of early antibiotic use on children’s gut microflora, Korpela and his team looked at 142 early-life children aged 2 to 7 years