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目的 :观察中西医结合治疗矽肺的疗效及机制。方法 :70例矽肺患者随机分成 2组 :中西医结合治疗组 4 0例 ,采用口服中药宣肺定喘丸和溶纤丸 ,并静滴复方丹参、维脑路通及双黄连注射液治疗 ;对照组 30例 ,采用口服氨茶碱、抗感染、必要时吸氧等对症治疗。 2组疗程均为 4周 ,观察肺功能变化及总有效率。结果 :中西医结合组总有效率为 95 .0 0 % ,对照组总有效率为 6 6 .6 7% ,2组比较有显著差异 (P<0 .0 1)。中西医结合治疗组治疗后肺活量 (VC)、1秒钟用力呼气容积 (FEV1 )及用力肺活量 (FVC)等均较治疗前及对照组治疗后有明显改善 (P均 <0 .0 5 ) ,临床症状和肺部体征消失时间较对照组显著缩短 (P均 <0 .0 1)。结论 :中西医结合治疗矽肺能改善症状、体征和肺功能 ,提高临床疗效
Objective: To observe the efficacy and mechanism of integrated traditional Chinese and western medicine in the treatment of silicosis. Methods: Seventy patients with silicosis were randomly divided into two groups: 40 cases in Integrative Medicine Group treated with Xuanfei Dingchuan Pills and Rongxian Pills, and treated with intravenous compound Danshen, Weitailu Tong and Shuanghuanglian Injection; Group 30 cases, oral aminophylline, anti-infection, if necessary, oxygen and other symptomatic treatment. The two courses of treatment were 4 weeks, observed changes in lung function and total effective rate. Results: The total effective rate was 95.0% in the combination of traditional Chinese medicine and western medicine, while the total effective rate in the control group was 66.76%. There was significant difference between the two groups (P <0.01). The volume of vital capacity (VC), forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) in the TCM combined treatment group were significantly improved after treatment (P <0.05) , Clinical symptoms and signs of lung disappeared significantly shorter than the control group (P all <0.01). Conclusion: Integrative treatment of silicosis can improve symptoms, signs and lung function and improve clinical efficacy