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目的:通过检测不同海拔地区孕晚期妇女血液微量元素特别是铁元素的变化,探讨高海拔地区铁元素变化与不良妊娠结局的关系,从而指导妊娠期妇女及时合理补充铁元素,为预防、治疗早产提供新的理论依据。方法:采用火焰原子吸收光谱法分别对玉树、西宁、咸阳三个不同海拔地区的正常晚孕组之间,以及同一地区的正常晚孕组与早产组之间的孕期母体血微量元素水平进行检测并分析对照。结果:不同海拔地区正常晚孕组中,玉树地区母体血清铁最低,西宁次之,咸阳地区母体血铁元素相对较高,差异均有统计学意义(均P<0.01),而同一地区正常晚孕组与早产组对照中发现,不论是玉树、西宁还是咸阳,早产组孕期妇女血Fe含量明显低于正常晚孕组,差异有统计学意义(P<0.01)。结论:西北地区海拔高度与孕晚期妇女血液中铁元素成负相关,早产妇女孕晚期血液铁元素明显低于正常足月分娩妇女孕晚期血液铁元素,表明孕晚期母体铁缺乏与早产具有相关性。
OBJECTIVE: To detect the changes of trace elements, especially iron, in blood of pregnant women in third trimester of pregnancy at different altitudes, and to explore the relationship between iron changes and adverse pregnancy outcomes in high altitude areas so as to guide pregnant women to timely and reasonably supply iron, and to prevent and treat preterm birth Provide a new theoretical basis. Methods: The levels of maternal serum trace elements during pregnancy were measured by flame atomic absorption spectrometry (FAAS) between normal late pregnancy groups at three different altitudes in Yushu, Xining and Xianyang, and between normal late pregnancy group and premature labor group in the same area And analyze the control. Results: In the normal pregnant group at different altitudes, the serum iron of maternal serum was the lowest in Yushu area, followed by that of Xining followed by Xianyang area, with significant difference (all P <0.01), while the normal night Pregnancy group and preterm birth control group found that both Yushu, Xining or Xianyang, preterm labor group of pregnant women, blood Fe levels were significantly lower than the normal pregnant group, the difference was statistically significant (P <0.01). Conclusion: The altitude of Northwest China is negatively correlated with iron in the blood of pregnant women in the third trimester. The blood iron level of preterm labor women is significantly lower than that of normal pregnant women in the third trimester of pregnancy. This indicates that the third trimester maternal iron deficiency is associated with preterm birth.