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目的探讨C-erb-B2和Ki67在胃癌中的表达,两者的相关性及与临床资料的关系。方法采用免疫组织化学SP法对78例胃癌组织标本进行染色,结合临床病理学特征,对C-erb-B2和Ki67在胃癌组织中的表达及临床意义进行探讨。结果 C-erb-B2和Ki67在胃癌组织中的表达率分别为25.6%和71.8%,C-erb-B2与胃癌的组织学分级,临床病理分期及淋巴结转移有关(P<0.05),Ki67与临床分期及淋巴结转移有关(P<0.05),C-erb-B2和Ki67表达强度呈显著正相关(P<0.05)。结论 C-erb-B2和Ki67在胃癌的进展中有协同作用,可作为反映胃癌生物学行为的指标。
Objective To investigate the expression of C-erb-B2 and Ki67 in gastric cancer, the relationship between the two and the relationship with clinical data. Methods The expression of C-erb-B2 and Ki67 in gastric cancer tissues and their clinical significance were studied by immunohistochemical SP method in 78 cases of gastric cancer tissues and clinicopathological features. Results The positive rates of C-erb-B2 and Ki67 in gastric cancer tissues were 25.6% and 71.8%, respectively. C-erb-B2 was correlated with histological grade, clinicopathologic stage and lymph node metastasis (P <0.05) Clinical stage and lymph node metastasis (P <0.05). There was a significant positive correlation between the expression of C-erb-B2 and Ki67 (P <0.05). Conclusions C-erb-B2 and Ki67 have synergistic effects on the progression of gastric cancer and can be used as an indicator of the biological behavior of gastric cancer.