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AIM:To investigate the effects of antireflux treatment onbronchial hyper-responsiveness and lung function inasthmatic patients with gastroesophageal reflux disease(GERD).METHODS:Thirty asthmatic patients with GERD wererandomly divided into two groups (group A and group B).Patients in group A (n=15) only received asthma medicationincluding inhaled salbutamol 200μg four times a day andbudesonide 400 μg twice a day for 6 weeks.Patients inGroup B (n=15) received the same medication as group A,and also antireflux therapy including oral omeprazole 20rng once a day and domperidone 10 mg three times a dayfor 6 weeks.Pulmonary function tests and histaminebronchoprovocation test were performed before and afterthe study.RESULTS:There was no significant difference in the baselinevalues of pulmonary function and histamine PC_(20-FEV1) betweenthe two groups.At the end of the study,the mean valuesfor VC,VC%,FVC,FVC%,FEV_1,FEV_1%,PEF,PEF%,PC_(20-FEV1)were all significantly improved in group B,compared withgroup A.CONCLUSION:Antireflux therapy may improve pulmonaryfunction and inhibit bronchial hyper-responsiveness inasthmatic patients with GERD.
AIM: To investigate the effects of antireflux treatment on bronchial hyper-responsiveness and lung function in patients with gastroesophageal reflux disease (GERD). METHODS: Thirty asthmatic patients with GERD were randomly divided into two groups (group A and group B). Patients in group A (n = 15) only received asthma medication containing 200 mg four times a day and budesonide 400 μg twice a day for 6 weeks. Patients in Group B (n = 15) received the same medication as group A, and also antireflux therapy including oral omeprazole 20 rng once a day and domperidone 10 mg three times a day for 6 weeks. Pulmonary function tests and histaminebronchoprovocation test were performed before and afterthe study .RESULTS: There was no significant difference in the baselinevalues of pulmonary function and histamine PC_ (20-FEV1) betweenthe two groups. At the end of the study, the mean values for VC, VC%, FVC, FVC%, FEV_1, FEV_1%, PEF, PEF%, PC20- FEV1 were all significantly improved in group B, compar ed withgroup A.CONCLUSION: Antireflux therapy may improve pulmonaryfunction and inhibit bronchial hyper-responsiveness inasthmatic patients with GERD.