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作者用光镜及电镜观察了15例肝细胞癌。用电镜观察了5例早期人胚肝作对比,两者在超微结构上有相似之处,这对电镜下判断肝细胞癌,特别是肝外转移的肝细胞癌有重要意义。两者也有较多差别,如癌细胞多形性,异质性,细胞结构成分的不同步分化,以及浸润性生长特点。这给电镜下判断肿瘤的良恶性,提供了重要依据。还观察了多个单个的死亡癌细胞,这些细胞虽未见凋落小体形成,但仍属癌细胞的凋落性死亡。在肝细胞癌半数病例中见到淋巴细胞溶癌现象,并可见较多大颗粒淋巴细胞
The author observed 15 cases of hepatocellular carcinoma with light and electron microscopy. The early human embryonic liver was observed by electron microscopy. There were similarities in the ultrastructure between the two cases. This is of great significance for judging hepatocellular carcinoma, especially extrahepatic metastatic hepatocellular carcinoma. There are also many differences between the two, such as the pleomorphism and heterogeneity of cancer cells, the asynchronous differentiation of cell structure components, and the characteristics of invasive growth. This provides an important basis for judging the benign and malignant tumors under electron microscope. A number of single dead cancer cells were also observed. Although these cells did not show the formation of leaf litter bodies, they were still dead due to the death of cancer cells. Lymphocytic leukemia was seen in half of cases of hepatocellular carcinoma and more large granular lymphocytes were seen