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用GC法测定生物样品中的甲胺磷(MAP),研究了iv、PC、SC和ig在家免和小鼠体内的毒物动力学,以全血ChE I(％)为毒效指标对MAP的PK—PD同步模型进行了初步探讨。MAP iv呈三室模型而PC、SC和ig均呈一级吸收一室模型。50％MAP乳剂经家兔皮肤吸收较快,不到3h吸收相基本结束,吸收率F为45％左右。SC的吸收速度比PC加快了十余倍,F高达97.6％,提示完整的皮肤对MAP具有一定的屏障作用。MAP经小鼠
Methamidophos (MAP) in biological samples was determined by GC method. The toxicokinetics of iv, PC, SC and ig in vivo and in mice were studied. PK-PD synchronization model for a preliminary study. MAP iv presents a three-compartment model and PC, SC and ig all present primary absorption one-compartment models. 50% MAP emulsion absorbed quickly through the skin of rabbits, and the absorption phase was almost completed in less than 3h. The absorption rate F was about 45%. The absorption rate of SC was more than ten times faster than that of PC, and the F was as high as 97.6%, suggesting that the intact skin had a certain barrier effect on MAP. MAP via mouse