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目的探讨口服碳酸氢钠治疗复发性外阴阴道假丝酵母菌病(RVVC)患者的效果。方法将2013年3月-2015年3月赣州市妇幼保健院收治的100例RVVC患者随机分为试验组和对照组各50例,两组患者均采用氟康唑顿服、克霉唑阴道上药治疗;同时试验组患者给予碳酸氢钠口服配合抗真菌治疗,对照组患者在阴道上药前加用2%碳酸氢钠片稀释后冲洗阴道。比较1周治愈率、3个月复发率及6个月和12个月复发率。结果试验组1周治愈率92.0%,3个月复发率0.0%,6个月复发率4.0%,12个月复发率6.0%;对照组1周治愈率88.0%,3个月复发率20.0%,6个月复发率34.0%,12个月复发率46.0%。两组患者1周治愈率差异无统计学意义(P>0.05),3、6、12个月复发率差异有统计学意义(P<0.05)。结论 RVVC患者接受抗真菌治疗同时给予碳酸氢钠口服可明显增加治愈率,同时降低复发率。
Objective To investigate the effect of oral sodium bicarbonate in patients with recurrent vulvovaginal candidiasis (RVVC). Methods From March 2013 to March 2015, 100 RVVC patients admitted to Ganzhou MCH hospital were randomly divided into experimental group and control group, 50 cases in each group. Fluconazole, clotrimazole vaginal At the same time, patients in the test group were given oral administration of sodium bicarbonate with antifungal therapy. Patients in the control group were treated with 2% sodium bicarbonate tablets before vaginal dosing to wash the vagina. One-week cure rates, 3-month recurrence rates, and 6-month and 12-month recurrence rates were compared. Results The cure rate of the experimental group was 92.0% in one week, 0.0% in 3 months, 4.0% in 6 months and 6.0% in 12 months. The cure rate in control group was 88.0% in 1 week and 20.0% in 3 months , 6 months recurrence rate 34.0%, 12 months recurrence rate 46.0%. There was no significant difference in the one-week cure rate between the two groups (P> 0.05). The recurrence rates at 3, 6 and 12 months were significantly different (P <0.05). Conclusion Anti-fungal treatment of patients with RVVC while oral administration of sodium bicarbonate can significantly increase the cure rate, while reducing the recurrence rate.