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从海南萝芙木生产“降压灵”的母液,经盐析得到生物碱部分,用硅胶柱层,制备薄层和葡聚糖凝胶过滤法,分得六种生物碱。碱Ⅰ(ajmaline)、碱Ⅱ(vellosimine)、碱Ⅲ(spegatrine)、碱Ⅳ(verticillatine)为已知碱,碱Ⅴ和碱Ⅵ为两个新的二聚体生物碱。根据红外、紫外、质谱、氢谱及碳谱等光谱分析,推定碱Ⅴ的化学结构为1式,命名为双斯配加春(dispegatrine)。并用半合成方法进一步确证了其结构.碱Ⅵ的结构待定.药理研究表明碱Ⅴ和碱Ⅵ均具有α-肾上腺素能受体阻断作用。
The mother liquor of “Ba Jiang Ling” was produced from Rauvolfia hainan, and the alkaloid fraction was obtained by salting out. A silica gel column layer was used to prepare a thin layer and a glucan gel filtration method to obtain six alkaloids. Ajmaline, vellosimine, spegatrine, and verticillatine are known bases, and base V and base VI are two new dimer alkaloids. According to spectral analysis of infrared, ultraviolet, mass spectrometry, hydrogen spectrum, and carbon spectrum, the chemical structure of base V was assumed to be 1 and was named as disgegrine. The structure was further confirmed by semi-synthetic method. The structure of base VI was to be determined. Pharmacological studies showed that both base V and base VI have α-adrenergic receptor blockade.