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目的探讨3.0T磁共振扫描仪(Siemens Trio Tim)磁化传递成像(MTI)在多发性硬化(MS)颈髓病变中的应用价值及其与临床的关系。资料与方法对11例伴颈髓病变的MS患者和20名健康自愿者行颈髓常规MRI和MTI。测量健康自愿者C2～7水平、MS患者MS斑块及正常表观颈髓(NACC)的磁化传递率(MTR),对其进行对照研究,并分析MTR与扩展病残状态评分(EDSS)之间的相关性。结果健康自愿者颈髓平均MTR值为(27.12±0.27)%,C2～7水平间颈髓MTR值差异无统计学意义(P>0.05)。MS斑块组、NACC组及对照组间的MTR值差异均具有统计学意义(P<0.05)。MS斑块组的MTR值与EDSS值存在高度负相关(r=-0.754,P=0.007)。结论颈髓MTI能发现MS患者T2WI病灶以外的隐匿性损伤,为判断损害程度提供信息。
Objective To investigate the clinical value of 3.0T magnetic resonance imaging (MTI) in the diagnosis of cervical spinal cord lesions with multiple sclerosis (MS). Materials and Methods Cervical spinal cord MRI and MTI were performed on 11 MS patients with cervical cord disease and 20 healthy volunteers. The level of magnetic transmission (MTR) in healthy volunteers from C2 to 7, MS patients with MS plaques and normal cervical spinal cord (NACC) was measured and compared with MTR and extended disability status score (EDSS) Relevance between. Results The mean MTR of cervical spinal cord in healthy volunteers was (27.12 ± 0.27)%, while there was no significant difference in MTR between C2 and 7 cervical spinal cord (P> 0.05). There were significant differences in MTR between MS plaque group, NACC group and control group (P <0.05). There was a highly negative correlation between MTR value and EDSS value in MS plaque group (r = -0.754, P = 0.007). Conclusion Cervical spinal cord MTI can detect occult lesions outside of T2WI lesions in MS patients and provide information for judging the extent of damage.