以4,6-二氯-5-氨基嘧啶为起始原料,利用聚乙二醇酸性双子离子液体(PEG1000-DAIL)为催化剂,通过3步反应合成了一系列6-氨基取代嘌呤衍生物并测试了其抑菌活性.与现有方法相比,该方法反应时间短且收率高,并能避免闭环过程中嘌呤6位氯的水解,目标化合物分离简单且离子液体易回收利用. A series of 6-amino-substituted purine derivatives were synthesized by 3-step reaction using 4,6-dichloro-5-aminopyrimidine as starting material and PEG1000-DAIL as catalyst The antibacterial activity of the purine was also tested.Compared with the existing methods, this method has the advantages of short reaction time and high yield, and can avoid the hydrolysis of purine 6-position chlorine in the ring closure process. The separation of the target compound is simple and the ionic liquid is easy to recycle.