The ability to perceive and respond to diverse noxious environmental stimuli, such as temperature (heat, cold),mechanical force (pinprick, pinch), and chemicals, is essential for keeping animals and humans away from damage.These stimuli are detected and encoded by nociceptors, a specialized group of somatosensory neurons with primary afferent fibers innervating the skin and with cell bodies located in the trigeminal and dorsal root ganglia(DRG) [1].