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目的:了解尿毒症患者血压昼夜节律特点。方法:选取尿毒症患者72例作为实验组,无心脑血管疾病的健康体检者70例为对照组。进行基本资料收集,分别监测7天平均24h动态血压变化。结果:两组比较,24h收缩压(24hSBP)、24h舒张压(24hDBP)均值;夜间收缩压(NSBP)、夜间舒张压(ND-BP)均值尿毒症患者明显高于对照组,具有显著性差异(P<0.01)。SBP夜间下降率(d-nSBP)尿毒症患者明显低于对照组。结论:尿毒症患者夜间血压持续升高,昼夜节律变化不明显,24h平稳降压对于改善预后,减轻靶器官受损至关重要。
Objective: To understand the circadian rhythm of blood pressure in patients with uremia. Methods: Seventy-two patients with uremia were selected as experimental group and 70 healthy subjects without cardiovascular disease as control group. Basic data collection, respectively, monitoring 7-day average 24h ambulatory blood pressure changes. Results: The 24h mean systolic blood pressure (24hSBP), mean 24h 24h diastolic pressure (24hDBP), nighttime systolic blood pressure (NSBP) and nighttime diastolic pressure (ND-BP) mean uremic patients were significantly higher than those of the control group (P <0.01). The rate of SBP decline at night (d-nSBP) was significantly lower in uremic patients than in controls. Conclusion: Uremic patients with nocturnal blood pressure continued to increase, circadian rhythm changes were not obvious, stable antihypertensive 24h to improve prognosis and reduce target organ damage is essential.