Polyethylene glycol(PEG-400): An efficient and recyclable reaction medium for the synthesis of novel

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A new series of imidazole-containing 1,5-benzodiazepines have been synthesized by the condensation of chalcones with ophenylenediamine using piperidine in polyethylene glycol(PEG-400)as an efficient and green reaction solvent.The advantages of this protocol are environmental friendliness,easy work-up,high yields,mild reaction condition and avoidance of expensive catalyst.Furthermore,newly synthesized compounds were evaluated for their antimicrobial activity.
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