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目的观察我国研制的规范化甲肝减毒活疫苗 (H2 株 )的流行病学保护效果。方法 35 15名甲肝易感儿童按出生单双月份随机分组 ,其中接种组 180 4名 ,对照组 16 5 3名。观察接种疫苗后两组甲型肝炎发病率。结果对照组发现甲肝病例 14例 ,发病率 8.47‰ ;疫苗组 1例 ,发病率 0 .5 5‰ ,保护率 93.5 1%,95 %下可信限为6 4.5 6 %。结论国产规范化甲肝减毒活疫苗与国外甲型肝炎灭活疫苗保护效果相似。
Objective To observe the epidemiological protective effect of normalized live attenuated hepatitis A vaccine (H2 strain) developed in China. Methods 35 15 children with hepatitis A were randomly divided into single and bimonthly births, of which 180 4 were inoculated and 16 53 in control group. The incidence of hepatitis A in both groups after vaccination was observed. Results In the control group, 14 cases of hepatitis A were found, the incidence rate was 8.47 ‰. In the vaccine group, the incidence was 0.55 ‰, the protection rate was 93.5 1%, and the 95% confidence limit was 6 4.56%. Conclusion Domestic normative attenuated live attenuated hepatitis A vaccine and foreign hepatitis A inactivated vaccine have similar protective effects.