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目的:探讨中药有毒成分分析研究的意义。方法:采用高效液相色谱法(HPLC)分析关木通及其配伍中药中有毒成分的含量,以此为例阐述中药有毒成分分析的意义。结果:关木通及其配伍中含有有毒成分马兜铃酸A,如临床用药稍有不慎,容易引起中毒甚至死亡。结论:对中药有毒成分进行分析研究,能揭示中药中的有毒成分的药效作用与毒性反应的物质基础,原理与规律,能为中医控制中药中的有毒作用而合理应用中药提供科学依据,且能为中药的现代化与国际化做出贡献,因此,应加强中药有毒成分分析的研究。
Objective: To explore the significance of the analysis of toxic components in traditional Chinese medicine. Methods: The contents of toxic components in Guanmutong and its compatibility were analyzed by high performance liquid chromatography (HPLC), and the significance of toxic components analysis of traditional Chinese medicine was expounded. Results: Guanmutong and its compatibility contains toxic ingredients aristolochic acid A, such as the clinical medication slightly careless, likely to cause poisoning and even death. Conclusion: The analysis of the toxic components in Chinese medicine can reveal the pharmacological effects and the material basis, principles and laws of the toxic components in traditional Chinese medicine, and provide a scientific basis for rational use of traditional Chinese medicine for the toxic effects of traditional Chinese medicine It can contribute to the modernization and internationalization of traditional Chinese medicine. Therefore, it is necessary to strengthen the research on toxic components analysis of traditional Chinese medicine.