有关长春新碱(VCR)急性神经毒性的报道逐渐增多,其中包括对三叉神经的影响。最常见的表现是颌骨的剧烈疼痛,其次是牙痛及咽痛。疼痛发生在药物应用后几小时内,可在几天后自动缓解。本研究的目的是观察使用VCR化疗的患者口腔颌面疼痛的发生率,分析其有关因素。方法选择40名首次使用VCR联合化疗的癌症 Reports of acute neurotoxicity of vincristine (VCR) have been reported, including the effects on the trigeminal nerve. The most common manifestations are jaw pain, followed by toothache and sore throat. Pain occurs within a few hours after the drug is applied and can be relieved automatically in a few days. The purpose of this study was to investigate the incidence of oral and maxillofacial pain in patients undergoing VCR chemotherapy and to analyze its associated factors. Methods Forty cancers were selected for the first time using VCR in combination with chemotherapy