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目的:为探讨运动和补充芦荟双重干预对糖尿病大鼠血脂的影响。方法:雄性SD大鼠100只,8周龄,体重190～210g,以50mg/kgBW剂量给大鼠一次性腹腔注射STZ。4天后测定大鼠尿糖和血糖,尿糖在+++至++++,血糖达16.67mmol/L以上者确定为糖尿病。随机选择造模成功的糖尿病大鼠48只分为4组,分别为安静组、运动组、补充芦荟安静组和补充芦荟运动组。两个运动组隔天以20m/min速度进行跑台训练1次,1h/次;两个补充芦荟组每天以0.4ml/只剂量用鲜库拉索芦荟汁灌胃。8周后测定血清HDL、LDL、TG、TC的变化。结果:运动组、补充芦荟安静组和补充芦荟运动组三个干预组大鼠HDL显著高于安静组(P<0.05,P<0.01);LDL、TG、TC显著低于安静组(P<0.05,P<0.01)。结论:运动或补充芦荟鲜汁能降低糖尿病大鼠血清LDL含量,提高HDL水平,降低血液中脂质成份TG、TC的含量;运动和补充芦荟共同干预对改善糖尿病大鼠血脂代谢有协同作用,能更有效地降低糖尿病大鼠血液中的脂质成份,提高血清HDL水平,对预防糖尿病心脑血管并发症有重要意义。
Objective: To investigate the effects of exercise and aloe vera double intervention on blood lipids in diabetic rats. Methods: One hundred male Sprague-Dawley rats, 8 weeks old, weighing 190-210 g, were given a single intraperitoneal injection of STZ at a dose of 50 mg / kg BW. Four days later, urine glucose and blood glucose were measured, and urine sugar was found to be +++ to ++++, with a blood glucose level of 16.67 mmol / L or more as diabetes. Forty-eight diabetic rats randomly selected for modeling were divided into 4 groups: Quiet group, exercise group, Quiet group supplemented with Aloe vera and Aloe vera exercise group. Two exercise groups performed treadmill training at a speed of 20 m / min for 1 h every other day, and the two supplemented aloe groups were orally administered with fresh aloe vera juice at a dose of 0.4 ml per day. After 8 weeks, the changes of serum HDL, LDL, TG and TC were measured. Results: The HDL of rats in exercise group, Aloe vera quiet group and Aloe vera exercise group were significantly higher than that of sedentary group (P <0.05, P <0.01); LDL, TG, TC were significantly lower than those of sedentary group , P <0.01). Conclusion: Exercise or supplementation of aloe vera juice can reduce serum LDL levels and increase HDL levels in diabetic rats, and lower the levels of TG and TC in the blood. Exercise combined with aloe vera has synergistic effects on improving blood lipid metabolism in diabetic rats, Can more effectively reduce the blood lipid components of diabetic rats, improve serum HDL levels, diabetes prevention of cardiovascular and cerebrovascular complications of great significance.