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TGF-β_1在激活肝星状细胞,促进细胞外基质大量合成中起关键作用,而TGF-β_1的激活是发挥其生理功能的首要条件。本文就TGF-β_1的激活机制及其与肝纤维化的关系的研究进展作一综述。
TGF-|Â1 plays a key role in activating hepatic stellate cells and promoting large-scale extracellular matrix synthesis. Activation of TGF-|Â1 is the first condition to exert its physiological function. This review summarizes the research progress of the mechanism of TGF-β 1 activation and its relationship with hepatic fibrosis.