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目的探讨控制多重心血管危险因素对代谢综合征(MS)患者早期肾功能损害的影响。方法619例住院患者分为高血压(EH)组144例(男/女,74/70),2型糖尿病(T2DM)组134例(男/女,79/55),MS组341例(男/女,167/174)。判断患者血压、血糖及血脂控制情况与早期肾功能损害的关系。结果MS和EH组均有50%以上的患者血压控制差,MS和T2DM组均有50%以上的患者血糖控制差;MS组中肥胖者占49%,显著高于T2DM和EH组;MS组中有50%以上的患者血脂紊乱,TG升高和HDL-C降低发生率显著高于T2DM和EH组。血压、血糖和血脂控制差的MS患者微量白蛋白尿(MA)出现率和内生肌酐清除率(Ccr)降低的发生率显著高于控制好的患者。结论MS患者早期肾功能损害较单纯高血压、糖尿病更显著,严格控制血压、血糖及血脂,积极调脂治疗,能起到保护MS患者肾功能的作用。
Objective To investigate the influence of multiple cardiovascular risk factors on early renal impairment in patients with metabolic syndrome (MS). Methods Six hundred and seventy-nine inpatients with hypertension were enrolled in this study. They were divided into two groups: 134 cases (male / female, 74/70) in hypertension group, 134 cases (79/55) in type 2 diabetes mellitus group / Female, 167/174). To determine the relationship between patients with blood pressure, blood glucose and lipid control and early renal dysfunction. Results In the MS and EH groups, over 50% of the patients had poor blood pressure control. In the MS and T2DM groups, over 50% of the patients had poor glycemic control. In the MS group, obesity was 49%, significantly higher than that in the T2DM and EH groups More than 50% of patients with dyslipidemia, TG increased and HDL-C decreased significantly higher incidence of T2DM and EH group. The incidence of microalbuminuria (MA) and reduction of endogenous creatinine (Ccr) in MS patients with poor blood pressure, blood glucose, and lipid profile were significantly higher than those in well-controlled patients. Conclusion MS patients with early renal impairment than simple hypertension, diabetes more significant, strict control of blood pressure, blood glucose and blood lipids, active lipid-lowering treatment, can play a protective role of renal function in MS patients.