目的探讨支气管肺泡灌洗联合无创通气对常规治疗失败的重症哮喘患者肺功能及病情缓解时间的影响。方法选择常规治疗失败的重症哮喘患者41例,随机分为两组,对照组和灌洗组。一组给予无创通气治疗,一组在上述治疗的同时给予支气管肺泡灌洗。结果灌洗组的肺功能PEF,FVC较对照组升高(P<0.05),症状改善时间及ICU住院天数较对照组缩短(P<0.05)。结论支气管肺泡灌洗联合无创通气应用于常规治疗失败的重症哮喘,肺功能恢复快,症状缓解时间及ICU住院天数短。 Objective To investigate the effects of bronchoalveolar lavage combined with noninvasive ventilation on pulmonary function and the duration of remission in patients with severe asthma who failed to receive conventional treatment. Methods Forty-one patients with severe asthma who failed routine treatment were randomly divided into two groups: control group and lavage group. One group received noninvasive ventilation and one group received bronchoalveolar lavage simultaneously with the above treatments. Results The pulmonary function PEF and FVC of the lavage group were higher than those of the control group (P <0.05), and the time of symptom improvement and hospital stay were shorter than those of the control group (P <0.05). Conclusions Bronchoalveolar lavage combined with noninvasive ventilation is applied to severe asthma with failed conventional treatment, rapid recovery of pulmonary function, time to symptom relief, and short hospital stay in ICU.