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目的:考察胰岛素注射液与注射用头孢地嗪钠在5%葡萄糖注射液中配伍稳定性。方法:观察配伍液外观、测定配伍液pH,不溶性微粒数等,采用HPLC法测定头孢地嗪钠含量,用化学发光免疫法测定胰岛素含量。结果:配伍液在6 h内无明显外观、pH,头孢地嗪钠含量的变化;但不溶性微粒(≥10μm)数在5 h后超过25个/ml,胰岛素含量在4 h后变化超过10%。结论:胰岛素注射液与头孢地嗪钠在5%葡萄糖注射液中室温下可配伍应用,但应在4 h内用完。
Objective: To investigate the compatibility of insulin injection and cefodizime sodium injection in 5% glucose injection. Methods: To observe the appearance of compatibility liquid, determine the pH of compatibility liquid and the number of insoluble particles. The content of cefodizime sodium was determined by HPLC and the content of insulin was determined by chemiluminescence immunoassay. Results: There was no obvious appearance, pH and the content of cefodizime sodium in the compatibility solution within 6 h. However, the number of insoluble particles (≥10 μm) exceeded 25 / ml after 5 h and the insulin content changed more than 10% after 4 h. . Conclusion: Insulin injection and cefodizime sodium can be used compatibly in 5% glucose injection at room temperature, but should be used within 4 h.