磷酸三甲苯酯(TCP)能引起人和动物多发性神经炎,并最终导致手足麻痹。虽然发病机理细节不清,但该病发生与神经病靶酯酶(NTE)不可逆性的抑制和老化有关。邻位TCP比对位和间位TCP的毒性大。 1988年7月印度加尔各答西南部的白哈拉地区发生一起食用菜子油中毒事件。约有600人中毒,343人(男203人、女140人)住院,但无死亡。经取样分析,鉴定中毒原因系菜子油被TCP污染所致。其中6个样品TCP含量达22～57%。对65个家庭135例(男82人、女53人,平均年龄28.25岁)患者进行仔细检查,估计每家在2.44±0.44天(均数±标准误)内污染油摄 Tricresyl phosphate (TCP) causes polyneuritis in humans and animals and eventually paralysis of the hands and feet. Although the pathogenesis of the details is unclear, but the disease occurs with the irreversibility of neuropathy target esterase (NTE) inhibition and aging. Orthologous TCP alignment and meta TCP are highly toxic. In July 1988, a case of edible rapeseed oil poisoning occurred in the Hakhara district of southwestern Kolkata in India. About 600 people were poisoned, 343 (203 males and 140 females) were hospitalized but none died. After sampling analysis, identify the cause of poisoning due to TCP pollution caused by rapeseed oil. Among them, TCP content of 6 samples reached 22 ~ 57%. In 65 families, 135 patients (82 males and 53 females, mean age 28.25 years) were carefully examined and each was estimated to have contaminated oil at 2.44 ± 0.44 days (mean ± standard error)