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Background:Sarpogrelate is a selective 5-hydroxytryptamine (5-HT) receptor subtype 2A antagonist which blocks 5-HT induced platelet aggregation and proliferation of vascular smooth muscle cells.We compared the efficacy of sarpogrelate-based dual antiplatelet therapies for the prevention of restenosis and target lesion revascularization (TLR) rates comparing with that of clopidogrel after percutaneous endovascular interventions (EVIs) of femoropopliteal (FP) arterial lesions.Methods:This prospective,multicenter,randomized clinical trial recruited a total of 120 patients with successful EVI of FP lesions at seven centers across China between January 2011 and June 2012.Patients were randomized to receive either sarpogrelate (1 00 mg trice daily for 6 months,n =63) or clopidogrel (75 mg once daily for 6 months,n =57).All patients also received oral aspirin (100 mg once daily for 12 months).Clinical follow-up was conducted up to 12 months postprocedure.Results:There was no significant difference between the two groups in basic demographic data.The restenosis rate was higher in the clopidogrel group (22.80％) than in sarpogrelate group (17.50％),but there was no significant difference between these two groups (P =0.465).The TLR rate,ipsilateral amputation rate,mortality in all-cause and bleeding rate were also similar in the two groups (P ＞ 0.05).Conclusions:Aspirin plus sarpogrelate is a comparable antithrombotic regimen to aspirin plus clopidogrel after EVI of FP arterial lesions.Dual antiplatelet therapies might play an important role in preventing restenosis after successful EVI of FP lesions.