自1996年高效抗逆转录病毒疗法(HAART)用于治疗HIV-1感染以来,已使HIV所致的发病率与死亡率明显降低,但HIV-1感染者何时开始HAART效果最佳尚未确定。作者通过对1054例HIV-1感染妇女的长期随访,探讨了在临床病毒学和免疫学不同阶段开始HAART与病情进展至艾滋病或死亡的相关性,从而确定开始HAART的最佳时间。 通过调查问卷每月对受试者随访一次,并进行体检和血样检测。HAART方案包括四种:(1)2种或 Since 1996, HAART has been used to treat HIV-1 infection, the morbidity and mortality caused by HIV have been significantly reduced, but the optimal timing of HAART has not been established for HIV-1 infected individuals . By long-term follow-up of 1,054 HIV-1 infected women, the authors explored the association between HAART and progression or AIDS / death at different stages of clinical virology and immunology to determine the optimal time to start HAART. Subjects were followed monthly by questionnaire, and physical examination and blood test were performed. HAART program includes four kinds: (1) 2 kinds or