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目的:探讨氯沙坦配合加味六味地黄汤对老年糖尿病肾病(DN)早期尿微量白蛋白排泄率(UAE)的影响。方法:62例随机分为治疗组和对照组,治疗组31例用氯沙坦、加味六味地黄汤;对照组31例用哌唑嗪。两组均用糖适平、维生素E、潘生丁。观察24hUAE、肾小球滤过率((GFR)、平均动脉压(MAP)的变化。结果:治疗组极显著地减少老年DN的UAE,并明显优于对照组(P=0.000)。治疗组使肾小球高滤过恢复正常,并优于对照组(P=0.000)。两组治疗后MAP均降至正常。结论:氯沙坦配合加味六味地黄汤显著减少老年DN的UAE。
Objective: To investigate the effect of losartan and Jiawei Liuwei Dihuang decoction on urinary albumin excretion rate (UAE) in senile diabetic nephropathy (DN). Methods: Sixty-two cases were randomly divided into treatment group and control group. The treatment group was treated with Losartan and Modified Liuweidihuang Decoction and the control group with prazosin. Both groups were using sugar-level, vitamin E, dipyridamole. The changes of 24hUAE, glomerular filtration rate (GFR) and mean arterial pressure (MAP) were observed.Results: The treatment group significantly reduced the UAE of elderly DN and was significantly better than the control group (P = 0.000) The hyperfiltration of glomerular returned to normal, and was superior to the control group (P = 0.000) .After treatment, MAP decreased to normal in both groups.Conclusion: Losartan and Jiawei Liuweidihuang Decoction significantly reduce the UAE of elderly DN.