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目的了解抗Sm抗体阳性系统性红斑狼疮(SLE)病人的临床特征。方法对42例抗Sm抗体阳性的SLE门诊病人临床资料进行分析,并与40例抗Sm抗体阴性SLE病人的临床资料进行比较。结果抗Sm抗体阳性的SLE病人病程较短,光敏感、关节痛、白细胞减少、蛋白尿下降、补体C3下降的发生率均高于对照组(t=7.38,χ2=3.60~10.98,P<0.05、0.01)。结论抗Sm抗体阳性SLE病人的临床表现明显,更易于做出早期诊断。抗Sm抗体阳性病人更易早期出现肾脏损害,提示预后不良。
Objective To understand the clinical features of patients with anti-Sm antibody-positive systemic lupus erythematosus (SLE). Methods The clinical data of 42 anti-Sm antibody-positive SLE outpatients were analyzed and compared with the clinical data of 40 anti-Sm antibody-negative SLE patients. Results SLE patients with anti-Sm antibody had a shorter course of disease, the incidence of photosensitivity, arthritis, leucopenia, proteinuria and C3 decreased (t = 7.38, χ2 = 3.60-10.98, P <0.05 , 0.01). Conclusion The clinical manifestations of anti-Sm antibody-positive SLE patients are obvious, and it is easier to make early diagnosis. Anti-Sm antibody positive patients more prone to early kidney damage, suggesting that the prognosis is poor.