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目的分析血清C反应蛋白和降钙素水平对早产儿脓毒血症预后的价值。方法选取2012年6月—2014年6月鹿邑县人民医院儿科治疗的182例脓毒血症早产儿为研究对象,监测血清C反应蛋白和降钙素原水平,记录临床资料,并观察预后情况。结果存活组患儿的胎龄大于死亡组,发病日龄长于死亡组,出生体重高于死亡组,两组间比较差异显著(P<0.05)。存活组患儿随治疗天数增加,血清CRP和PCT水平均逐渐降低且均小于死亡组,差异显著(P<0.05);而死亡组患儿的血清CRP和PCT水平均随治疗天数增加基本无变化,差异不显著(P>0.05)。存活患儿与死亡患儿的NCIS分级差异显著(P<0.05)。结论血清C反应蛋白和降钙素水平对早产儿脓毒血症预后预测具有重要的临床价值。
Objective To analyze the prognostic value of serum C-reactive protein and calcitonin in preterm infants with sepsis. Methods A total of 182 septic preterm infants treated in Luyi County People’s Hospital from June 2012 to June 2014 were enrolled in this study. Serum C-reactive protein and procalcitonin levels were monitored, clinical data were recorded and prognosis was observed Happening. Results The gestational age of surviving group was higher than that of death group, the age of onset was longer than that of death group, and the birth weight was higher than that of death group. There was significant difference between the two groups (P <0.05). The CRP and PCT levels in survivors increased gradually with the increase of treatment days, and the serum levels of CRP and PCT decreased gradually, both of which were significantly lower than those of death group (P <0.05). However, serum CRP and PCT levels in death group remained unchanged with the increase of treatment days , The difference was not significant (P> 0.05). The difference of NCIS grade between surviving children and those with death was significant (P <0.05). Conclusions Serum C-reactive protein and calcitonin levels have important clinical value in predicting prognosis of sepsis in preterm infants.