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目的:探究癌胚抗原(CEA)、组织多肽特异性抗原(TPS)与癌抗原(CA125)联合检测在卵巢癌中的诊断价值。方法:应用酶联免疫吸附试验与电化学发光全自动免疫分析仪检测98例卵巢肿瘤患者(其中卵巢癌42例,卵巢良性肿瘤56例)的血清TPS与CEA、(CA125),并与健康体检者60例作对照。结果:卵巢癌组患者的CEA、TPS以及CA125水平显著高于卵巢良性肿瘤组和健康对照组,差异具有统计学意义(P<0.05);三者进行联合检测的敏感度和准确度均显著高于单独检测的效能指标,差异有统计学意义(P<0.05)。结论:CEA、TPS以及CA125联合检测对于卵巢恶性肿瘤的诊断价值优于只检测单一任何一种肿瘤标志物,有效的联合检测可提高对卵巢癌诊断的敏感性,同时对疗效的观察及病情监测有重要价值。
Objective: To investigate the diagnostic value of combined detection of carcinoembryonic antigen (CEA), tissue polypeptide specific antigen (TPS) and cancer antigen (CA125) in ovarian cancer. Methods: Serum TPS and CEA, (CA125) were detected in 98 cases of ovarian cancer patients (including 42 cases of ovarian cancer and 56 cases of ovarian benign tumor) by enzyme-linked immunosorbent assay and chemiluminescence immunoassay. 60 cases as a control. Results: The levels of CEA, TPS and CA125 in patients with ovarian cancer were significantly higher than those in benign ovarian tumors and healthy controls (P <0.05). The sensitivity and accuracy of the three tests were significantly higher There was a significant difference in the efficacy indexes tested separately (P <0.05). Conclusions: The combined detection of CEA, TPS and CA125 is superior to the detection of any single tumor marker in ovarian cancer. Effective combination detection can improve the sensitivity of ovarian cancer diagnosis. At the same time, the curative effect observation and condition monitoring Have important value.