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目的 分析CA12 5和AFP在原发性肝癌患者血清中的表达情况。 方法 采用放免分析对 6 3例原发性肝癌患者进行血清CA12 5和AFP的检测 ,统计分析两项指标的表达情况 ,并进行比较。结果 CA12 5和AFP的含量分别为 172 8± 2 0 0 5ku/L ,2 6 2 4± 2 86 3ug/L。以CA12 5 >35ku/L ,AFP>2 0ug/L为原发性肝癌诊断标准 ,其阳性率分别为 6 9 8%和 6 8 3% ,两者联合检测阳性率为 87 3%。统计学Ridit分析 ,两者表达阳性率无显著性差异 ;相关性分析 ,两者无线性相关关系存在。CA12 5和AFP单项检查的阳性率分别与联合检查的阳性率进行X2 检验 ,均有显著性差异 (P <0 0 5 )。结论 CA12 5是一项较好的原发性肝癌诊断标志物 ,与AFP阳性率无显著性差异 ,与AFP无相关性。联合检测可显著提高诊断阳性率。
Objective To analyze the expression of CA12 5 and AFP in serum of primary liver cancer patients. Methods The radioimmunoassay was used to detect the serum CA12 5 and AFP in 63 patients with primary liver cancer. The expression of the two indexes was statistically analyzed and compared. Results The contents of CA12 5 and AFP were 172 8±2 0 5 ku/L and 2 6 2 4± 286 3ug/L, respectively. CA12 5 >35 ku/L and AFP>2 0 ug/L were the diagnostic criteria for primary liver cancer, and the positive rates were 6.98% and 683% respectively. The positive rate of the combined detection was 87%. Statistical Ridit analysis, there was no significant difference in the positive rate of the two; correlation analysis, there is a wireless correlation between the two. The positive rate of CA12 5 and AFP individual examinations and the positive rate of joint examinations were examined by X2. There were significant differences (P < 0.05). Conclusion CA12 5 is a good diagnostic marker for primary hepatic carcinoma, and there is no significant difference between AFP positive rate and AFP. Combined detection can significantly increase the diagnostic positive rate.