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目的探讨乌司他丁(UTI)对多脏器功能障碍综合征(MODS)的治疗作用。方法将106例MODS患者随机分为UTI)治疗组和对照组,观察两组第1、10天血常规、CRP、肝肾功能及急性生理与慢性健康评估Ⅱ(APACHEⅡ)评分,并进行比较。结果与对照组比较,治疗组第10天WBC、ALT、总胆红索、肌酐、CRP、APACHElI评分降低、血小板升高,第21天病死率下降(P均<0.05)。结论乌司他丁治疗多脏器功能障碍综合征患者具有良好的临床效果。
Objective To investigate the therapeutic effect of ulinastatin (UTI) on multiple organ dysfunction syndrome (MODS). Methods 106 patients with MODS were randomly divided into treatment group and control group. The blood routine, CRP, liver and kidney function and acute physiology and chronic health assessment Ⅱ (APACHE Ⅱ) scores of the two groups were observed and compared on the 1st and 10th days. Results Compared with the control group, the WBC, ALT, total bilirubin, creatinine, CRP and APACHElI score decreased, thrombocytopenia decreased and the morbidity decreased on the 21st day (all P <0.05). Conclusion Ulinastatin in patients with multiple organ dysfunction syndrome has a good clinical effect.