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目的:观察内异丸对大鼠子宫内膜异位模型的影响。方法:采用手术移植法造成大鼠子宫内膜异位模型,观察口服给药内异丸对子宫内膜移植物体积、孕激素含量及血液流变性的影响;采用大鼠角叉菜胶致足肿胀模型观察药物抗炎作用;采用醋酸致小鼠疼痛模型观察药物镇痛作用。结果:内异丸具有抑制移植性子宫内膜生长作用,以及抗炎、镇痛作用。结论:内异丸对子宫内膜异位症具有一定的治疗作用。
Objective: To observe the effect of Neiyin Pill on rat model of endometriosis. METHODS: The rat model of endometriosis was induced by surgical implantation. The effects of oral administration of Neiyiwan on endometrial graft volume, progesterone content and hemorheology were observed. The swelling model was used to observe the anti-inflammatory effects of the drug; the analgesic effect of the drug was observed using an acetic acid induced mouse pain model. RESULTS: Neiyipeng has the effect of inhibiting the growth of transplanted endometrium, as well as anti-inflammatory and analgesic effects. Conclusion: Neiyiwan has a certain therapeutic effect on endometriosis.