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干细胞是目前生物医学的研究热点之一。近年研究发现肝脏中存在多种具有不同标志物的干细胞,在肝脏再生中具有重要作用;自体及异体干细胞移植治疗终末期肝病也取得了一定进展。但肝干细胞的来源及标志物尚未完全阐明,肝干细胞的增殖和分化调控机制仍有待深入研究。随着谱系追踪技术、干细胞分离和培养体系的发展与成熟,肝干细胞的来源及其在肝再生中的作用将会进一步明确,肝病干细胞治疗有望成为现实。
Stem cells are one of the hot topics in biomedicine. In recent years, studies have found that there are many kinds of stem cells with different markers in the liver, which play an important role in liver regeneration. Some progress has also been made in the treatment of end-stage liver disease with autologous and allogeneic stem cell transplantation. However, the sources and markers of hepatic stem cells have not yet been completely elucidated. The regulation mechanism of hepatic stem cells proliferation and differentiation remains to be further studied. With the tracing of pedigree technology, the development and maturation of stem cell isolation and culture system, the origin of liver stem cells and their role in liver regeneration will be further clarified, liver stem cell therapy is expected to become a reality.