Boiler-circuit system in a circulating fluidized bed combustion boiler is a complex and typical industrial process with a large lag and time-delay. Conventional PID algorithm can not obtain satisfied performance, especially in the presence of disturbance. A cascade generalized predictivecontrol (CGPC) strategy, is which the inner loop can restrain the disturbance while the outer loop can eliminate the offset, is proposed in this paper. We develop cascade GPC algorithm instead of conventional PID algorithm in the boiler-circuit system. Simulation on experimental boiler-circuit models of circulating fluidized bed combustion boiler shows strong robustness.