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[目的]调查无贫血男性青年中MCV降低者的比例和对其原因做初步探讨。[方法]测定1242名参加中山市2007年征兵体检无贫血男性青年的MCV,统计MCV降低的比例;对MCV降低者进行网织红细胞、RBC渗透脆性、涂片检查小球型红细胞、血清铁蛋白、HbA2含量、α-地贫基因测定。[结果]无贫血男性青年MCV降低的比例为11.8%;RBC渗透脆性MCV降低组与MCV正常组差异无统计学意义;103例MCV降低者中无小球形RBC超过5%;101例MCV降低无贫血男性青年中无血清铁蛋白浓度低于参考范围下限者;103例MCV降低标本中HbA2﹥3.5%者41例,占39.4%;20例MCV降低标本中11例α珠蛋白基因缺失,占55.0%,其中-a3.7/aa2例、--SEA/aa9例;网织红细胞计数MCV降低组与MCV正常组差异无统计学意义,在地中海贫血者中仅17.3%超出参考范围上限1.82%。[结论]无贫血男性青年中存在相当比例MCV降低者,导致这一情况的主要病因为地中海贫血。
[Objective] To investigate the proportion of non-anemic male youth with decreased MCV and to make a preliminary study on its causes. [Methods] A total of 1242 MCVs who participated in the male physical examination in Zhongshan City were enrolled in this study. The proportion of MCV decreased in MCV decreased in 2007; the infiltration fragility of reticulocytes, , HbA2 content, α-thalassemia gene assay. [Results] The percentage of MCV decreased in non-anemic male youth was 11.8%. There was no significant difference between MCBC reduced RBC infiltration fragility MCV normal group and 103 cases MCV reduced in no MCR more than 5% 41 cases (39.4%) had HbA2> 3.5% in 103 cases with MCV reduction, and 11 cases had α-globin gene deletion in 20 cases with MCV reduction, accounting for 55.0% %, Of which -a3.7 / aa2 cases, - SEA / aa9 cases; reticulocyte count MCV reduction group and MCV normal group was no significant difference, only 17.3% of thalassemia patients than the upper limit of reference range of 1.82%. [Conclusions] There is a significant proportion of MCV-less men without anemia, leading to the major cause of thalassemia.