促性腺激素释放激素激动剂(GnRH-a)是体外受精-胚胎移植(IVF-ET)技术中重要用药。GnRH-a与GnRH受体结合后,早期“突发”作用可刺激垂体促性腺激素急剧释放,持续应用后使垂体受抑制,内源性促性腺激素(Gn)水平下降,即所谓的降调节作用。利用这种生物学特性,GnRH-a联合Gn超促排卵可预防早发黄体生成素(LH)峰,避免卵泡过早黄素化。另外,GnRH-a代替人绒毛膜促性腺激素诱发排卵可降低卵巢过度刺激综合征(OHSS)发生率。探索既能有效抑制LH峰,又不使垂体过度抑制的GnRH-a有效低剂量对于超促排卵有重要意义。 Gonadotropin-releasing hormone agonist (GnRH-a) is an important drug used in IVF-ET (in vitro fertilization-embryo transfer) technology. GnRH-a and GnRH receptor binding, early “burst ” effect can stimulate the rapid release of pituitary gonadotropin, pituitary suppression continued after the application of endogenous gonadotropin (Gn) levels, the so-called Down regulation. Using this biological properties, GnRH-a in combination with Gn hyperstimulation prevents premature ovulation luteinizing hormone (LH) peaks and avoids premature luteinization of follicles. In addition, GnRH-a instead of human chorionic gonadotropin-induced ovulation can reduce ovarian hyperstimulation syndrome (OHSS) incidence. To explore both effectively inhibit the LH peak, without excessive inhibition of pituitary GnRH-a effective low dose for ovarian hyperstimulation is important.