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目的:研究槲皮苷对糖尿病大鼠血糖的作用。方法:选择原发性糖尿病大鼠模型(GK),将其分为槲皮苷组、格列齐特组、二甲双胍组、空白组、正常组(Wistar大鼠)。分别给与药物干预,空白组与正常组给与生理盐水。2周后,观察GK体质量、进食量、空腹血糖、糖耐量、空腹C肽等指标,观察槲皮苷对于2型糖尿病大鼠血糖的影响。结果:给药后,槲皮苷组和二甲双胍组大鼠体质量呈进行性下降(P<0.05),且明显低于其他组(P<0.05)。二甲双胍与格列齐特组进食量不断减少(P<0.05),且明显低于其他组(P<0.05)。槲皮苷组大鼠给药2周后空腹血糖较前改善明显(P<0.05),显著低于空白组(P<0.05),但空腹血糖改善作用弱于二甲双胍与格列齐特组(P<0.05)。槲皮苷组大鼠给药后糖耐量较前有显著改善(P<0.05),明显优于空白组(P<0.05)。给药2周后,槲皮苷组大鼠C肽水平较前有明显升高(P<0.05),且显著高于空白组(P<0.05);槲皮苷组大鼠C肽水平低于格列齐特组(P<0.05),而与二甲双胍组基本相当(P>0.05)。结论:槲皮苷能显著降低GK大鼠体质量及空腹血糖,改善糖耐量异常,升高空腹C肽水平。揭示槲皮苷对于糖尿病大鼠存在降血糖作用。且其作用机制可能与促进胰岛素分泌,改善胰岛素抵抗有关。
Objective: To study the effect of quercitrin on blood glucose in diabetic rats. Methods: Primary diabetic rat model (GK) was selected and divided into quercetin group, gliclazide group, metformin group, blank group and normal group (Wistar rats). Drug interventions were given respectively, and normal saline was given to the blank group and the normal group. Two weeks later, the body weight, food intake, fasting blood glucose, glucose tolerance, fasting C-peptide and other indexes of GK were observed to observe the effect of quercitrin on blood glucose in type 2 diabetic rats. Results: After administration, the body weight of quercetin and metformin groups decreased progressively (P <0.05), and significantly lower than other groups (P <0.05). The food intake of metformin and gliclazide decreased continuously (P <0.05), and was significantly lower than other groups (P <0.05). Compared with the blank group, the fasting blood glucose of the quercitrin group was significantly improved two weeks after administration (P <0.05), but the improvement of fasting blood glucose was weaker than that of the metformin and gliclazide groups (P <0.05) <0.05). Compared with the former, quercetin significantly improved glucose tolerance (P <0.05), which was significantly better than the blank group (P <0.05). After 2 weeks of administration, the level of C-peptide in the quercitrin group was significantly higher than that in the control group (P <0.05), and significantly higher than that in the blank group (P <0.05) Gliclazide group (P <0.05), and with metformin group basically the same (P> 0.05). Conclusion: Quercitrin can significantly reduce body weight and fasting blood glucose in GK rats, improve glucose tolerance and increase fasting C-peptide levels. It is revealed that quercitrin has hypoglycemic effect on diabetic rats. And its mechanism may be related to promoting insulin secretion and improving insulin resistance.