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目的探讨血糖、血压、C反应蛋白、载脂蛋白与脑梗死进展的关系。方法对急性脑梗死(ACI)患者入院后行血糖(FBG)、载脂蛋白A(apoA)、载脂蛋白B(apoB)、C反应蛋白(CRP)检查,记录入院时收缩压(SBP),舒张压(DBP)。将FBG分为A组(≤8mmol/L)和B组(>8mmol/L),同样的方法将SBP(≤160mmHg,>160mmHg)、DBP(≤90mmHg,>90mmHg)、CRP(≤10mg/L,>10mg/L)、apoA(≤1·8g/L,>1·8g/L)、apoB(≤1·45g/L,>1·45g/L)各分为A、B两组,每组统计进展性脑梗死(ECI)和稳定性脑梗死(CCI)的例数,计算两组病例中ECI例数占总例数的比率(脑梗死进展率,ER)。用SPSS10·0统计软件对每项参数A、B组间ER逐一进行χ2检验,计算B组增加的脑梗死进展危险率(△ERCI)。△ERCI=(ERB-ERA)/ERA×100%。结果FBG、DBP、CRP、apoB等4项A、B组间ER差异有统计学意义,P<0·05。其中,FBG>8mmol/L、CRP>10mg/L、apoB>1·45g/L组相应地比FBG≤8mmol/L、CRP≤10mg/L、apoB≤1·45g/L组ER高,各增加67·3%、114·3%、92·9%。而DBP>90mmHg组比DBP≤90mmHg组脑梗死进展率下降,减少41·6%。结论入院时FBG、CRP、apoB升高和DBP下降的ACI病例更有进展的倾向,可作为进展的预测指标。
Objective To investigate the relationship between blood glucose, blood pressure, C-reactive protein, apolipoprotein and cerebral infarction. Methods Blood glucose (FBG), apolipoprotein A (apoB) and C-reactive protein (CRP) were measured in patients with acute cerebral infarction (ACI) after admission. Systolic blood pressure (SBP) Diastolic blood pressure (DBP). FBG was divided into group A (≤8mmol / L) and group B (> 8mmol / L). SBP (≤160mmHg,> 160mmHg), DBP , ApoA (≤1.8g / L,> 1.8g / L), apoB (≤1.45g / L,> 1.45g / L) were divided into A and B groups Group statistics of progressive cerebral infarction (ECI) and stable cerebral infarction (CCI) of the number of cases, the two groups of cases calculated ECI cases the proportion of the total number of cases (cerebral infarction progress rate, ER). SPSS 10.0 software was used to test the ER of each parameter A and B group one by one byχ2 test to calculate the increasing risk of cerebral infarction in group B (△ ERCI). △ ERCI = (ERB-ERA) / ERA × 100%. Results There were significant differences in ER between the 4 groups A and B of FBG, DBP, CRP and apoB, P <0 · 05. Among them, FBG> 8mmol / L, CRP> 10mg / L, apoB> 1.45g / L group were higher than FBG≤8mmol / L, CRP≤10mg / L, apoB≤1.45g / 67.3%, 114.3% and 92.9% respectively. The DBP> 90mmHg group DBP ≤ 90mmHg group decreased the progress rate of cerebral infarction, a decrease of 41.6%. Conclusions The incidence of FBG, CRP, apoB elevation and DBP decline in admission ACI patients more propensity to progress, can be used as a predictor of progress.